Connective tissue growth factor decreases mitochondrial metabolism through ubiquitin-mediated degradation of mitochondrial transcription factor A in oral squamous cell carcinoma

Role of Connective Tissue Growth Factor (CTGF/CCN2) in Oral Squamous Cell Carcinoma-Induced Bone Destruction

metabolic syndrome and mitochondrial transcription factor a

Vascular Endothelial Growth Factor in Serum and Saliva of Oral Lichen Planus and Oral Squamous Cell Carcinoma Patients

Background:Oral lichen planus (OLP) is considered as a potentially malignant disorder and vascular endothelial growth factor (VEGF) may play a key role in cancer development. The aim of this study was to compare serum and saliva VEGF among patients with OLP, oral squamous cell carcinoma (OSCC) and a healthy control group. Methods:A cross sectional study was pe...

Epidermal Growth Factor Receptor Expression in Oral Squamous Cell Carcinoma by Immunohistochemical Technique and its Correlation with Clinicopathological Features

Background:Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. Despite some improvements in treatment, the survival rate is still very low, mainly due to the possible development of secondary malignancy or metastasis. Clinical and pathological features as well as molecular biomarkers might predict the recurrence. In recent years, many studies ...

Altered expression of mitochondrial antioxidants in oral squamous cell carcinoma.

Reactive oxygen species, if produced in excess by oxidative phosphorylation, contributes to mitochondrial DNA damage and progressive respiratory chain dysfunction, leading to various diseases including carcinogenesis. Mitochondria are susceptible to oxidative stress (OS) owing to lack of introns, protective histones, and DNA repair enzymes. However, mitochondria are protected from OS by numerou...